"Loading COMMAND.COM" message can be seen on a HUD view of the Terminator and the internal viewport of RoboCop when he reboots.

In the CGI children's TV series ReBoot, which takes place inside computers, the leader of a system (the equivalent of a city) is called the COMMAND.COM.

The command.com domain once hosted a website with an image of a command prompt that has finished running the "dir" command on the root of an empty C drive. However, the resulting command incorrectly displayed the . and .. directories, which are never shown in the root of a drive.[10]