IGF-1 Chr. Chromosome 12 (human)[1] UniProt P05019 Location (UCSC) Chr 12: 102.4 – 102.48 Mb List of PDB id codes List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS Available structuresPDBList of PDB id codes Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS PubMed search [2] RefSeq (protein) NP_000609NP_001104753NP_001104754NP_001104755 Aliases IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF RefSeq (mRNA) NM_000618NM_001111283NM_001111284NM_001111285 PDB Human UniProt search: PDBe RCSB Gene ontologyMolecular functionCellular componentBiological process Gene ontologyMolecular function• hormone activity• insulin receptor binding• growth factor activity• integrin binding• GO:0001948 การจับกับโปรตีน• insulin-like growth factor receptor bindingCellular component• extracellular region• exocytic vesicle• insulin-like growth factor binding protein complex• platelet alpha granule lumen• insulin-like growth factor ternary complex• alphav-beta3 integrin-IGF-1-IGF1R complex• เยื่อหุ้มเซลล์• ภายนอกเซลล์Biological process• positive regulation of transcription regulatory region DNA binding• skeletal system development• positive regulation of glucose import• movement of cell or subcellular component• muscle organ development• positive regulation of Ras protein signal transduction• response to heat• positive regulation of cardiac muscle hypertrophy• positive regulation of smooth muscle cell migration• การถ่ายแบบดีเอ็นเอ• positive regulation of insulin-like growth factor receptor signaling pathway• phosphatidylinositol 3-kinase signaling• positive regulation of DNA binding• Ras protein signal transduction• cell population proliferation• positive regulation of mitotic nuclear division• positive regulation of trophectodermal cell proliferation• positive regulation of glycogen biosynthetic process• positive regulation of fibroblast proliferation• ERK1 and ERK2 cascade• negative regulation of extrinsic apoptotic signaling pathway• cell activation• negative regulation of oocyte development• positive regulation of transcription, DNA-templated• bone mineralization involved in bone maturation• positive regulation of peptidyl-tyrosine phosphorylation• positive regulation of MAPK cascade• proteoglycan biosynthetic process• positive regulation of activated T cell proliferation• positive regulation of epithelial cell proliferation• negative regulation of release of cytochrome c from mitochondria• protein stabilization• myotube cell development• positive regulation of DNA replication• myoblast proliferation• skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration• positive regulation of protein secretion• positive regulation of glycoprotein biosynthetic process• การควบคุมการแสดงออกของยีน• phosphatidylinositol-mediated signaling• positive regulation of smooth muscle cell proliferation• cellular protein metabolic process• muscle hypertrophy• protein kinase B signaling• regulation of multicellular organism growth• positive regulation of cell migration• platelet degranulation• positive regulation of calcineurin-NFAT signaling cascade• positive regulation of phosphatidylinositol 3-kinase signaling• myoblast differentiation• glycolate metabolic process• positive regulation of glycolytic process• negative regulation of smooth muscle cell apoptotic process• การถ่ายโอนสัญญาณ• positive regulation of transcription by RNA polymerase II• positive regulation of cell growth involved in cardiac muscle cell development• positive regulation of cell population proliferation• positive regulation of osteoblast differentiation• activation of protein kinase B activity• insulin-like growth factor receptor signaling pathway• การควบคุมเชิงลบต่ออะพอพโทซิส• positive regulation of tyrosine phosphorylation of STAT protein• regulation of signaling receptor activity• positive regulation of gene expression• negative regulation of gene expression• cellular response to amyloid-beta• positive regulation of vascular associated smooth muscle cell proliferation• negative regulation of vascular associated smooth muscle cell apoptotic process• negative regulation of interleukin-1 beta production• negative regulation of tumor necrosis factor production• negative regulation of neuroinflammatory response• negative regulation of amyloid-beta formationSources:Amigo / QuickGO Cellular component • extracellular region• exocytic vesicle• insulin-like growth factor binding protein complex• platelet alpha granule lumen• insulin-like growth factor ternary complex• alphav-beta3 integrin-IGF-1-IGF1R complex• เยื่อหุ้มเซลล์• ภายนอกเซลล์ External IDs OMIM: 147440 HomoloGene: 515 GeneCards: IGF1 End 102,481,744 bp[1] Ensembl ENSG00000017427 Molecular function • hormone activity• insulin receptor binding• growth factor activity• integrin binding• GO:0001948 การจับกับโปรตีน• insulin-like growth factor receptor binding Species Human RNA expression pattern RNA expression patternMore reference expression data BandStart 12q23.2 Biological process • positive regulation of transcription regulatory region DNA binding• skeletal system development• positive regulation of glucose import• movement of cell or subcellular component• muscle organ development• positive regulation of Ras protein signal transduction• response to heat• positive regulation of cardiac muscle hypertrophy• positive regulation of smooth muscle cell migration• การถ่ายแบบดีเอ็นเอ• positive regulation of insulin-like growth factor receptor signaling pathway• phosphatidylinositol 3-kinase signaling• positive regulation of DNA binding• Ras protein signal transduction• cell population proliferation• positive regulation of mitotic nuclear division• positive regulation of trophectodermal cell proliferation• positive regulation of glycogen biosynthetic process• positive regulation of fibroblast proliferation• ERK1 and ERK2 cascade• negative regulation of extrinsic apoptotic signaling pathway• cell activation• negative regulation of oocyte development• positive regulation of transcription, DNA-templated• bone mineralization involved in bone maturation• positive regulation of peptidyl-tyrosine phosphorylation• positive regulation of MAPK cascade• proteoglycan biosynthetic process• positive regulation of activated T cell proliferation• positive regulation of epithelial cell proliferation• negative regulation of release of cytochrome c from mitochondria• protein stabilization• myotube cell development• positive regulation of DNA replication• myoblast proliferation• skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration• positive regulation of protein secretion• positive regulation of glycoprotein biosynthetic process• การควบคุมการแสดงออกของยีน• phosphatidylinositol-mediated signaling• positive regulation of smooth muscle cell proliferation• cellular protein metabolic process• muscle hypertrophy• protein kinase B signaling• regulation of multicellular organism growth• positive regulation of cell migration• platelet degranulation• positive regulation of calcineurin-NFAT signaling cascade• positive regulation of phosphatidylinositol 3-kinase signaling• myoblast differentiation• glycolate metabolic process• positive regulation of glycolytic process• negative regulation of smooth muscle cell apoptotic process• การถ่ายโอนสัญญาณ• positive regulation of transcription by RNA polymerase II• positive regulation of cell growth involved in cardiac muscle cell development• positive regulation of cell population proliferation• positive regulation of osteoblast differentiation• activation of protein kinase B activity• insulin-like growth factor receptor signaling pathway• การควบคุมเชิงลบต่ออะพอพโทซิส• positive regulation of tyrosine phosphorylation of STAT protein• regulation of signaling receptor activity• positive regulation of gene expression• negative regulation of gene expression• cellular response to amyloid-beta• positive regulation of vascular associated smooth muscle cell proliferation• negative regulation of vascular associated smooth muscle cell apoptotic process• negative regulation of interleukin-1 beta production• negative regulation of tumor necrosis factor production• negative regulation of neuroinflammatory response• negative regulation of amyloid-beta formation Gene location (Human)Chr.BandStartEnd Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q23.2Start102,395,874 bp[1]End102,481,744 bp[1] Entrez 3479
