↑ Connah's Quay Nomads will play their home match at Park Avenue, Aberystwyth, instead of their regular stadium Deeside Stadium, Connah's Quay, which did not meet UEFA requirements.
↑ Shkëndija will play their home match at Toše Proeski Arena, Skopje, instead of their regular stadium Ecolog Arena, Tetovo, which did not meet UEFA requirements.
↑ Shakhtyor Soligorsk played their home match at Čukarički Stadium, Belgrade (Serbia), instead of their regular stadium Stroitel Stadium, Soligorsk, as in June UEFA suspended all matches to be played in Belarus in 2021, due to European Union sanctions in response to the Ryanair Flight 4978 incident, including banning all European airlines from flying over Belarusian airspace.[35]
